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Gut microbiota, immunity and pain

2020; Elsevier BV; Volume: 229; Linguagem: Inglês

10.1016/j.imlet.2020.11.010

1879-0542

Matteo Santoni, Francesca Miccini, Nicola Battelli,

Clostridium difficile and Clostridium perfringens research

The interplay between microbiota and nervous system has been associated with a variety of diseases, including stress, anxiety, depression and cognition. The growing body of evidences on the essential role of gut microbiota in modulating acute and chronic pain has opened a new frontier for pain management. Gut microbiota is involved in the development of visceral, inflammatory and neuropathic pain. Bacterial alterations due to chronic opioid administration have been directly related to the development of drug tolerance, which can be potentially restored by the use of probiotics and antibiotics. In this review we describe the mechanisms underlying the brain/gut axis and the relationship between gut microbiota, immunity and pain.