Portal de Periódicos da CAPES

Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance

2020; Multidisciplinary Digital Publishing Institute; Volume: 6; Issue: 4 Linguagem: Inglês

10.3390/jof6040321

2309-608X

Hans Carolus, Siebe Pierson, Katrien Lagrou, Patrick Van Dijck,

Nematode management and characterization studies

Although polyenes were the first broad spectrum antifungal drugs on the market, after 70 years they are still the gold standard to treat a variety of fungal infections. Polyenes such as amphotericin B have a controversial image. They are the antifungal drug class with the broadest spectrum, resistance development is still relatively rare and fungicidal properties are extensive. Yet, they come with a significant host toxicity that limits their use. Relatively recently, the mode of action of polyenes has been revised, new mechanisms of drug resistance were discovered and emergent polyene resistant species such as