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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

2020; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês

10.1038/s41467-020-19733-6

2041-1723

Valgerður Steinthórsdóttir, Ralph McGinnis, Nicholas Williams, Lilja Stefánsdóttir, Guðmar Þorleifsson, Scott Shooter, João Fadista, Jon K. Sigurdsson, Kirsi Auro, Galina Berezina, Maria Carolina Borges, Suzannah Bumpstead, Jonas Bybjerg‐Grauholm, Irina Colgiu, Vivien A. Dolby, Frank Dudbridge, Stephanie M. Engel, Christopher Franklin, Michael L. Frigge, Yr Frisbæk, Reynir Tómas Geirsson, Frank Geller, Sólveig Grétarsdóttir, Daníel F. Guðbjartsson, Quaker E. Harmon, David M. Hougaard, Tatyana Hegay, Anna Helgadóttir, Sigrun Hjartardottir, Tiina Jääskeläinen, Hrefna Johannsdottir, Ingileif Jónsdóttir, Thorhildur Juliusdottir, Noor Kalsheker, A. K. Kasimov, John P. Kemp, Katja Kivinen, Kari Klungsøyr, Wai Lee, Mads Melbye, Zosia Miedzybrodska, Ashley Moffett, Dilbar Najmutdinova, F Nishanova, Thorunn A. Olafsdottir, Markus Perola, Fiona Broughton Pipkin, Lucilla Poston, Gordon Prescott, Saedís Saevarsdóttir, Damilya Salimbayeva, Paula J. Scaife, Line Skotte, Eleonora Staines-Urias, Ólafur Andri Stefánsson, Karina Meden Sørensen, Liv Cecilie Vestrheim Thomsen, Vinicius Tragante, Lill Trogstad, Nigel Simpson, Hannele Laivuori, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Linda Morgan, Fiona Broughton Pipkin, Noor Kalsheker, James J. Walker, Sheila Macphail, Mark D. Kilby, Marwan Habiba, Catherine Williamson, Kevin M. O’Shaughnessy, Shaughn O’Brien, Alan C. Cameron, Christopher W.G. Redman, Martin Farrall, Mark J. Caulfield, Anna F. Dominiczak, Tamara Aripova, Juan P. Casas, Anna F. Dominiczak, James J. Walker, Unnur Þorsteinsdóttir, Ann‐Charlotte Iversen, Bjarke Feenstra, Debbie A. Lawlor, Heather A. Boyd, Per Magnus, Hannele Laivuori, Nodira Zakhidova, Gulnara Svyatova, Kāri Stefánsson, Linda Morgan,

Gestational Diabetes Research and Management

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.