Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

2020; BMJ; Volume: 10; Issue: 12 Linguagem: Inglês

10.1136/bmjopen-2019-035307

2044-6055

A. E. Ades, Elizabeth B. Brickley, Neâl Alexander, David Brown, Thomas Jaenisch, Demócrito de Barros Miranda-Filho, Moritz Pohl, Kerstin Daniela Rosenberger, Antoni Soriano‐Arandes, Claire Thorne, Ricardo Arraes de Alencar Ximenes, Thália Velho Barreto de Araújo, Vivian Iida Avelino‐Silva, Sarah Esperanza Bethencourt Castillo, Víctor Hugo Borja Aburto, Patrícia Brasil, C D C Christie, Wayner Vieira de Souza, Jose Eduardo Gotuzzo H, Bruno Hoen, Marion Koopmans, Celina Maria Turchi Martelli, Mauro Martins Teixeira, Ernesto T. A. Marques, María Consuelo Miranda, Ulísses Ramos Montarroyos, Maria Elisabeth Lopes Moreira, J. Glenn Morris, Barry Rockx, Paola Mariela Saba Villarroel, Carmen Soria Segarra, Adriana Tami, Marília Dalva Turchi, Carlo Giaquinto, Xavier de Lamballerie, Annelies Wilder‐Smith,

COVID-19 Impact on Reproduction

Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean. Methods and analysis We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach. Ethics and dissemination Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.