High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants
2020; American Academy of Pediatrics; Volume: 146; Issue: Supplement_4 Linguagem: Inglês
10.1542/peds.2020-023861p
ISSN1098-4275
Autores Tópico(s)Child and Adolescent Health
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AAP Policy SupplementsSupplements Publish Supplement MultimediaVideo Abstracts Pediatrics On Call Podcast Subscribe Alerts Careers We will not be accepting article comments until November 8, 2021, while our site undergoes major changes. We apologize for the inconvenience. For questions, contact the editorial office. Allergy High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants Kelly Boyd and J. Andrew Bird Pediatrics December 2020, 146 (Supplement 4) S330; DOI: https://doi.org/10.1542/peds.2020-023861P Kelly Boyd Dallas, TexasFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteJ. Andrew Bird Dallas, TexasFind this author on Google ScholarFind this author on PubMedSearch for this author on this site ArticleInfo & MetricsComments Download PDF J Rosendahl, AS Pelkonen, O Helve. J Pediatr. 2019;209:139–145.e1PURPOSE OF THE STUDY:To examine the effect of post-natal vitamin D supplementation on the development of allergic disease in the first year of life.STUDY POPULATION:The study included 987 infants born to mothers of Northern European descent in Finland. Inclusion criteria included term birth with an appropriate weight for gestational age and newborns not requiring higher levels of care. The study population was followed from birth until 12 months of age.METHODS:The study was a double-blinded randomized control trial. The study population was randomly divided into two vitamin D supplementation groups: one group received daily vitamin D3 of 400 IU (10 μg) and the other group received daily vitamin D3 of 1200 IU (30 μg). At the time of delivery, pregnancy serum samples and cord blood were analyzed for 25(OH)D concentration. At 12 months of age, 25(OH)D concentration was measured for each infant as well as specific IgE antibodies to food allergens and aeroallergens. Parents of the 12-month-old infants also completed an allergy questionnaire that included questions regarding whether the infant had ever been diagnosed with food allergy, asthma, wheezing, or eczema.RESULTS:There was no statistically significant difference between allergic diseases in infants receiving different doses of vitamin D supplementation. IgE sensitization at 12 months of age to food allergens and aeroallergens was observed in 16% and 4% of all infants enrolled in the study, respectively. There was no difference between the two groups in the development of eczema, asthma, or IgE sensitization to food allergens or aeroallergens. Physician-diagnosed cow milk allergy was higher in the group receiving higher vitamin D supplementation, but there was no difference in specific IgE to cow milk between the groups. In infants with cord blood 25(OH)D concentration greater than 100 nmol/L, the risk for IgE sensitization to food allergens was higher, compared with those with a lower cord blood vitamin D.CONCLUSIONS:Increased post-natal vitamin D supplementation does not decrease the risk of allergic disease in infants. There was an increased risk of cow milk allergy in infants with higher vitamin D levels and an increase in allergic disease in those with higher cord blood vitamin D.REVIEWER COMMENTS:The incidence of allergic disease has drastically increased over the past twenty years, and vitamin D deficiency has been hypothesized as a potential cause. Multiple studies have been conducted that demonstrate an association between low vitamin D levels and allergic disease but it is not clear if this is a causal relationship. This study is the first randomized control trial looking at the effect of vitamin D supplementation on the development of allergic disease in infants, and further studies need to be done to include a more diverse population and those at higher risk for developmental of allergic disease.Copyright © 2020 by the American Academy of Pediatrics PreviousNext Back to top Advertising Disclaimer » In this issue Pediatrics Vol. 146, Issue Supplement 4 1 Dec 2020 Table of ContentsIndex by author View this article with LENS PreviousNext Email Article Thank you for your interest in spreading the word on American Academy of Pediatrics.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Andrew Bird Pediatrics Dec 2020, 146 (Supplement 4) S330; DOI: 10.1542/peds.2020-023861P Citation Manager Formats BibTeXBookendsEasyBibEndNote (tagged)EndNote 8 (xml)MedlarsMendeleyPapersRefWorks TaggedRef ManagerRISZotero Share High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants Kelly Boyd, J. Andrew Bird Pediatrics Dec 2020, 146 (Supplement 4) S330; DOI: 10.1542/peds.2020-023861P Share This Article: Copy Print Download PDF Insight Alerts Table of Contents Jump to section ArticlePURPOSE OF THE STUDY:STUDY POPULATION:METHODS:RESULTS:CONCLUSIONS:REVIEWER COMMENTS:Info & MetricsComments Related ArticlesNo related articles found.Google Scholar Cited By...No citing articles found.Google Scholar More in this TOC SectionAllergy Dog Ownership at 3 Months of Age is Associated With Protection Against Food Allergy Staphylococcus aureus Antibiotic Susceptibility Patterns in Pediatric Atopic Dermatitis Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood Show more Allergy Risk Factors and Prevention of Atopy Endotoxin, Food Allergen Sensitization, and Food Allergy: A Complementary Epidemiologic and Experimental Study Postnatal Probiotics and Allergic Disease in Very Preterm Infants: Sub-study to the ProPrems Randomized Trial Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma Show more Risk Factors and Prevention of Atopy Similar Articles Journal Info Editorial Board Editorial Policies Overview Licensing Information Authors/Reviewers Author Guidelines Submit My Manuscript Open Access Reviewer Guidelines Librarians Institutional Subscriptions Usage Stats Support Contact Us Subscribe Resources Media Kit About International Access Terms of Use Privacy Statement FAQ AAP.org shopAAP Follow American Academy of Pediatrics on Instagram Visit American Academy of Pediatrics on Facebook Follow American Academy of Pediatrics on Twitter Follow American Academy of Pediatrics on Youtube RSS © 2021 American Academy of Pediatrics
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