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Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study

2020; American Association for Cancer Research; Volume: 30; Issue: 2 Linguagem: Inglês

10.1158/1055-9965.epi-20-0732

1538-7755

Alice Hinchliffe, Manolis Kogevinas, Beatriz Pérez‐Gómez, Eva Ardanáz, Pilar Amiano, Alba Marcos‐Delgado, Gemma Castaño‐Vinyals, Javier Llorca, Vı́ctor Moreno, Juan Alguacil, Guillermo Fernández‐Tardón, Dolores Salas, Rafael Marcos‐Gragera, Núria Aragonés, Marcela Guevara, Leire Gil, Vicente Martín, Yolanda Benavente, Inés Gómez‐Acebo, Miguel Santibáñez, Miguel Ángel Baeza Alba, Ana M. García, Marina Pollán, Michelle C. Turner,

Heat shock proteins research

Background: Mechanisms linking occupational heat exposure with chronic diseases have been proposed.However, evidence on occupational heat exposure and cancer risk is limited.Methods: We evaluated occupational heat exposure and female breast cancer risk in a large Spanish case-control study.We enrolled 1,738 breast cancer cases and 1,910 frequencymatched population controls.A Spanish job-exposure matrix, MatEmEsp, was used to assign estimates of the proportion of workers exposed (P ≥ 25% for at least 1 year) and work time with heat stress (wet bulb globe temperature ISO 7243) for each occupation.We used three exposure indices: ever versus never exposed, lifetime cumulative exposure, and duration of exposure (years).We estimated ORs and 95% confidence intervals (CI), applying a lag period of 5 years and adjusting for potential confounders.Results: Ever occupational heat exposure was associated with a moderate but statistically significant higher risk of breast cancer (OR 1.22; 95% CI, 1.01-1.46),with significant trends across categories of lifetime cumulative exposure and duration (P trend ¼ 0.01 and 0.03, respectively).Stronger associations were found for hormone receptor-positive disease (OR ever exposure ¼ 1.38; 95% CI, 1.12-1.67).We found no confounding effects from multiple other common occupational exposures; however, results attenuated with adjustment for occupational detergent exposure.Conclusions: This study provides some evidence of an association between occupational heat exposure and female breast cancer risk.Impact: Our results contribute substantially to the scientific literature.Further investigations are needed considering multiple occupational exposures.