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Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a

2020; Elsevier BV; Volume: 292; Linguagem: Inglês

10.1016/j.virusres.2020.198233

1872-7492

Khajohn Joonlasak, Elizabeth M. Batty, Theerarat Kochakarn, Bhakbhoom Panthan, Krittikorn Kümpornsin, Poramate Jiaranai, Arporn Wangwiwatsin, Angkana T. Huang, Namfon Kotanan, Peera Jaru-Ampornpan, Wudtichai Manasatienkij, Treewat Watthanachockchai, Kingkan Rakmanee, Anthony R. Jones, Stefan Fernandez, Insee Sensorn, Somnuek Sungkanuparph, Ekawat Pasomsub, Chonticha Klungthong, Thanat Chookajorn, Wasun Chantratita,

Viral gastroenteritis research and epidemiology

Coronavirus Disease 2019 (COVID-19) is a global public health threat. Genomic surveillance of SARS-CoV-2 was implemented in March of 2020 at a major diagnostic hub in Bangkok, Thailand. Several virus lineages supposedly originated in many countries were found, and a Thai-specific lineage, designated A/Thai-1, has expanded to be predominant in Thailand. A virus sample in the SARS-CoV-2 A/Thai-1 lineage contains a frame-shift deletion at ORF7a, encoding a putative host antagonizing factor of the virus.