Produção Nacional
Revisado por pares
Is metabolically healthy obesity indeed healthy at the microvascular level?
2020; Oxford University Press; Volume: 41; Issue: Supplement_2 Linguagem: Inglês
10.1093/ehjci/ehaa946.3028
ISSN1522-9645
AutoresEduardo Tibiriçá, Grazielle Vilas Bôas Huguenin, Luiz Fernando Rodrigues, Daniela Peçanha, Marco Antonio Peña Duque, Silas Escobar, Alice Pereira Duque, Christiane F Araújo, Mauro Felippe Felix Mediano, Andrea De Lorenzo,
Tópico(s)Heart Rate Variability and Autonomic Control
ResumoAbstract Background In the current “obesity epidemic”, obese individuals without insulin resistance, lipid disorders, or hypertension, have been called “metabolically healthy” (MHO) and considered to have intermediate cardiovascular risk, between that of healthy nonobese (HNO) individuals and of metabolically unhealthy obese (MUO). Nonetheless, this is controversial, as MHO may have subclinical abnormalities, and indeed may be a transitory state in the way to the unhealthy phenotype. Purpose To evaluate systemic microvascular reactivity in MHO, MUO and HNO. Methods Ten MHO, 10 MUO and 20 HNO individuals were studied. Obesity was considered as a BMI ≥30 kg/m2. The NCEP/ATPIII criteria, excluding waist circumference, were used to define the metabolically healthy phenotype (absence of all criteria) or unhealthy phenotype (presence of any of the criteria). Laser speckle contrast imaging coupled with skin acetylcholine (Ach) iontophoresis was employed to study cutaneous microvascular reactivity (endothelial-dependent vasodilatation), as a surrogate for systemic microvascular function, and cutaneous vascular conductance [CVC in arbitrary perfusion units of microvascular flow (APU)/mean arterial pressure (mmHg)] was measured. Results Mean age was 34.8, 36.7 and 32.3 years (P=0.17, ANOVA) and BMI was 20.7, 32.2 and 33.3 kg/m2 (P<0.0001) for HNO, MHO and MUO, respectively. Both MHO and MUO had significantly decreased microvascular vasodilation in comparison to HNO (Figure 1). Of note, there was no significant difference between MHO and MUO regarding CVC (both similarly decreased when compared to the healthy controls). Conclusions This study underscores that MHO is not a “benign” condition, as it has adverse effects on microvascular function, similarly to those found in MUO. The study of cutaneous microvascular function may be useful to identify subclinical abnormalities in obese individuals who might deserve more intensive management. Figure 1 Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): FAPERJ - Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro - Brazil
Referência(s)