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Eosinopenia in COVID-19 Patients: A Retrospective Analysis

2020; Multidisciplinary Digital Publishing Institute; Volume: 8; Issue: 12 Linguagem: Inglês

10.3390/microorganisms8121929

2076-2607

Narcisse Ndieugnou Djangang, Lorenzo Peluso, Marta Talamonti, Antonio Izzi, Pierre Alain Gevenois, Alessandra Garufi, Jean‐Christophe Goffard, Sophie Henrard, Paolo Severgnini, Jean‐Louis Vincent, Jacques Créteur, Fabio Silvio Taccone,

Thermal Regulation in Medicine

Objectives: The aim of this study was to assess the diagnostic role of eosinophils count in COVID-19 patients. Methods: Retrospective analysis of patients admitted to our hospital with suspicion of COVID-19. Demographic, clinical and laboratory data were collected on admission. Eosinopenia was defined as eosinophils < 100 cells/mm3. The outcomes of this study were the association between eosinophils count on admission and positive real-time reverse transcription polymerase chain reaction (rRT-PCR) test and with suggestive chest computerized tomography (CT) of COVID-19 pneumonia. Results: A total of 174 patients was studied. Of those, 54% had positive rRT-PCR for SARS-CoV-2. A chest CT-scan was performed in 145 patients; 71% showed suggestive findings of COVID-19. Eosinophils on admission had a high predictive accuracy for positive rRT-PCR and suggestive chest CT-scan (area under the receiver operating characteristic—ROC curve, 0.84 (95% CIs 0.78–0.90) and 0.84 (95% CIs 0.77–0.91), respectively). Eosinopenia and high LDH were independent predictors of positive rRT-PCR, whereas eosinopenia, high body mass index and hypertension were predictors for suggestive CT-scan findings. Conclusions: Eosinopenia on admission could predict positive rRT-PCR test or suggestive chest CT-scan for COVID-19. This laboratory finding could help to identify patients at high-risk of COVID-19 in the setting where gold standard diagnostic methods are not available.