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Renal alterations caused by ligature‐induced periodontitis persist after ligature removal in rats

2020; Wiley; Volume: 56; Issue: 2 Linguagem: Inglês

10.1111/jre.12822

1600-0765

Juliana Gomes Galeno, Luíz Felipe de Carvalho França, Felipe Rodolfo Pereira da Silva, Even Herlany Pereira Alves, David Di Lenardo, Hélio Mateus Silva Nascimento, Any Carolina Cardoso Guimarães Vasconcelos, Paulo Roberto Carneiro Gomes, Manoel Dias de Souza Filho, Vinícius da Silva Caetano, Ana Patrícia de Oliveira, Marcus Vinícius Oliveira Barros de Alencar, André Luiz dos Reis Barbosa, Jand Venes Rolim Medeiros, Farahnaz Fahimipou, Silvana P. Barros, Ivana Márcia Alves Diniz, Daniel Fernando Pereira Vasconcelos,

Dental Erosion and Treatment

Abstract Background and Objective Periodontitis may crosstalk with renal diseases, yet that remains unclear. We investigated whether the renal alterations caused by induced periodontitis are reversible after removal of the ligatures in experimental ligature‐induced periodontitis. Material and methods Twenty‐four female rats were divided into three groups: control (without periodontitis), periodontitis (20 days of ligature‐induced periodontitis), and P20‐20 (20 days of ligature‐induced periodontitis and 20 days after ligature removal). The following periodontal parameters were assessed: gingival bleeding index, probing pocket depth, myeloperoxidase activity, and alveolar bone height. For renal tissues, histopathology, malonaldehyde (MDA) levels, glutathione (GSH) content, and renal weight were evaluated. In the blood, creatinine, uric acid, albumin, total cholesterol, total protein, and glucose levels were assessed. Total protein and creatinine levels in urine were also investigated. Results Rat renal tissues did not demonstrate reversal of periodontitis‐related changes in the P20‐20 group in terms of MDA, GSH, and histopathological evaluations when compared to the periodontitis group. Accordingly, only total cholesterol levels were reversible in the P20‐20. Conclusion Renal alterations caused by ligature‐induced periodontitis persisted even after removal of ligatures in rats.