Portal de Periódicos da CAPES

Artigo Produção Nacional

BIBTEX RIS

Maternal and Obstetrical Outcomes in a Cohort of Pregnant Women Tested for SARS-CoV-2: Interim Results of the COVI-Preg International Registry

2020; RELX Group (Netherlands); Linguagem: Inglês

10.2139/ssrn.3684424

1556-5068

Manon Vouga, Guillaume Favre, Óscar Martínez Pérez, Léo Pomar, Laura Forcén Acebal, Alejandra Abascal, Marı́a Rosa Hernández, Najeh Hcini, Véronique Lambert, Gabriel Carles, Joanna Sichitiu, Laurent Salomon, Julien Stiremann, Y. Ville, Begoña Martínez de Tejada, Anna Goncé, Ameth Hawkins-Villareal, Karen CA, E. Gratacós, Lucas Trigo, Brian Cleary, Michael Geary, Helena C. Bartels, Feras Al-Kharouf, Fergal D. Malone, Mary Higgins, Niamh Keating, Susan Knowles, C. Poncelet, Carolina C. Ribeiro‐do‐Valle, Fernanda Ribeiro-do-Valle, Garanhani Surita, Amanda Dantas‐Silva, Carolina Bicudo Borrelli, Adriana Gomes Luz, Javiera Fuenzalida, Manuel Guerra Canales, Olivia Allende Hernández, Olga Grechukhina, Albert I. Ko, Uma M. Reddy, Rita Figueiredo, Marina Moucho, Pedro Viana Pinto, Carmen De Luca, Marco De Santis, Diogo Ayres‐de‐Campos, Charles Garabédian, D. Subtil, Betânia Barreto de Athayde Bohrer, Maria Oppermann, María Celeste, Osório Wender, Lavínia Schüler‐Faccini, Maria Teresa Vieira Sanseverino, Camila Giugliani, Luciana Friedrich, Mariana Horn Scherer, Nicolas Mottet, Guillaume Ducarme, Hélène Pelerin, Chloé Moreau, Bénédicte Breton, T. Quibel, Patrick Rozenberg, D Mueller, Cristina Granado, Irène Hoesli, Cécile Monod, Dirk Bassler, Sandra A. Heldstab, Nicole Ochsenbein‐Kölble, Loı̈c Sentilhes, Melissa Charvet, Jan Deprest, Jute Richter, Lennart Van der Veeken, Béatrice Eggel-Hort, Gaëtan Plantefève, Mohamed Derouich, Albaro José Nieto‐Calvache, María Camila López-Girón, Juan Manuel Burgos‐Luna, María Fernanda Escobar-Vidarte, Kurt Hecher, Ann‐Christin Tallarek, Eran Hadar, Karina Krajden Haratz, G. Malinger, Ron Maymon, Yariv Yogev, Leonhard Schäffer, Arnaud Toussaint, Marie-Claude Rossier, Renato Augusto Moreira de Sá, Claudia Grawe, Karoline Aebi‐Popp, Anda‐Petronela Radan, Luigi Raio, Daniel Surbek, Paul Böckenhoff, Brigitte Strizek, Martin Kaufmann, Andrea Bloch, Michel Boulvain, Silke Johann, Monya Todesco Bernasconi, Gastón Grant, Anis Féki, Anne-Claude Müller Brochut, Marylene Giral, Lucie Sedille, Andrea Papadia, Romina Capoccia Brugger, Brigitte Weber, Tina Fischer, Christian R. Kahlert, Karin Nielsen Saines, Mary Catherine Cambou, P. Kanellos, Xiang Chen, Mingzhu Yin, Annina Haessig, David Baud, Alice Panchaud,

COVID-19 and healthcare impacts

Background: Pregnant women represent a vulnerable population at higher risk of complications of infectious diseases. Data regarding the consequences of the emerging pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy are scarce. Recent evidence suggests that pregnant women might be at higher risk of severe disease, while exposed fetuses and newborns could suffer from preterm birth, growth restriction and neonatal infections.Methods: We developed an international web registry to allow structured data collection. Pregnant women at any stage during gestation tested for SARS-CoV-2 infection were enrolled. Maternal, obstetrical and neonatal outcomes were recorded.Findings: 1033 pregnant women tested for SARS-CoV-2 were included, among which 926 tested positive and 107 tested negative. Positive pregnant women were at higher risk of severe maternal outcomes compared to negative women [aRR 5.6, 95% CI 1.4-22.7]. Risk factors for severe maternal outcomes among positive women were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. No difference in term of obstetrical and neonatal outcomes were observed between positive and negative women. Positive pregnant women with severe maternal outcomes were at higher risk of cesarean sections [70.7% (n=53/75)], preterm deliveries [62.7% (n= 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n=31/75)]. A positive neonatal SARS-CoV-2 test was observed in 2.9% (n=11/384) of newborns with an available test at birth.Interpretation: Pregnant women, particularly those with associated comorbidities, seem to be at higher risk of severe complications of SARS-CoV-2 infection. Preliminary data regarding obstetrical and neonatal outcomes among women with a mild disease are reassuring.Funding Statement: None.Declaration of Interests: The authors declare that we have no conflicts of interest.Ethics Approval Statement: The study was approved by both the Swiss Ethical Board (CER-VD-2020-00548) and the local ethics boards at each participating center.