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Characterization of G protein β subunit expression of human brain Glioma tumor

2020; AEPress; Volume: 121; Issue: 12 Linguagem: Inglês

10.4149/bll_2020_148

1336-0345

Mehdi Pooladi, Maliheh Entezari, Mehrdad Hashemi,

Genetics, Bioinformatics, and Biomedical Research

Proteome indicates the protein content of a genome.Proteome analysis is effective in a new system formulation and prediction, prevention, and treatment based on protein.One of the purposes of proteomics researches is to know and understand the cancer mechanism.In this study, we separated the proteins by the Two-Dimensional Electrophorese method and analyzed and compared protein spots by statistical and software data.The spots were separated and identifi ed by the proteins' Isoelectric PH differences, molecular weights, and data bank.In continuation, the protein profi les were clustered by MALDI-TOF-TOF and the main element was identifi ed and confi rmed.We have used site PhosphoSitePlus® to review post-translational modifi cations.The fi ndings indicated that the G protein Beta subunit rate increased in the astrocytoma, oligodendroglia, and glioblastoma cerebral malignant tumors.The βγ complex formation may prevent and activates many paths of cellular growth.The βγ complex activity control of the changes after the conversion parallel to GTPase activity of this α subunit may be a formulation mechanism for the G signal path (Tab.5, Fig. 4, Diagram 2, Ref. 29).