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Trained immunity, tolerance, priming and differentiation: distinct immunological processes

2020; Nature Portfolio; Volume: 22; Issue: 1 Linguagem: Inglês

10.1038/s41590-020-00845-6

1529-2916

Maziar Divangahi, Peter Aaby, Shabaana A. Khader, Luis B. Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R. DiNardo, Jorge Domínguez‐Andrés, Raphaël Duivenvoorden, Stephanie Fanucchi, Zahi A. Fayad, Elaine Fuchs, Mélanie Hamon, Kate L. Jeffrey, Nargis Khan, Leo A. B. Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, J.W.M. van der Meer, Musa M. Mhlanga, Simone J.C.F.M. Moorlag, Willem J. M. Mulder, Shruti Naik, Boris Novakovic, Luke O'neill, Jordi Ochando, Keiko Ozato, Niels P. Riksen, Robert W. Sauerwein, Edward R. Sherwood, Andreas Schlitzer, Joachim L. Schultze, Michael H. Sieweke, Christine Stabell Benn, Henk G. Stunnenberg, Joseph C. Sun, Frank L. van de Veerdonk, Sebastian Weis, David L. Williams, Ramnik J. Xavier, Mihai G. Netea,

Vaccine Coverage and Hesitancy

The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.