Produção Nacional
Revisado por pares
Genes and SNPs in the pathway of immune response and caries risk: a systematic review and meta-analysis
2020; Taylor & Francis; Linguagem: Inglês
10.1080/08927014.2020.1856821
ISSN1029-2454
AutoresLuiz Alexandre Chisini, Mariana Gonzalez Cademartori, Marcus Cristian Muniz Conde, Francine dos Santos Costa, Luciana Tovo‐Rodrigues, Rodrigo Varella de Carvalho, Flávio Fernando Demarco, Marcos Britto Corrêa,
Tópico(s)Dental Health and Care Utilization
ResumoThe aim of this systematic review and meta-analysis was to pool the data on Single Nucleotide Polymorphisms (SNPs) in immune response genes associated with dental caries. Nineteen studies were included in the review and 18 in the meta-analysis. Twenty-two SNPs were evaluated, which are linked to six different genes (MBL2, LFT, MASP2, DEFB1, FCN2 and MUC5B). Most SNPs (81.8%) are related to the possible functional impact on protein coding. The MBL2 gene was associated with caries experience in the analysis of the homozygote (OR = 2.12 CI95%[1.12–3.99]) and heterozygote (OR = 2.22 CI95%[1.44–3.44]) genotypes. The MUC5B gene was associated according to an analysis of the heterozygous genotype (OR = 1.83 CI95%[1.08–3.09]). Thus, SNPs related to immune response genes are linked to the phenotype of caries experience. Although the meta-analysis showed that the genes MBL2 and MUC5B were associated with caries, these results should be interpreted with caution due to the quality of the evidence.
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