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Layered cryogels laden with Brazilian honey intended for wound care

2020; Associação Brasileira de Polímeros; Volume: 30; Issue: 3 Linguagem: Inglês

10.1590/0104-1428.06820

1984-7386

Gabriela de Souza dos Santos, Natália Rodrigues Rojas dos Santos, Ingrid Cristina Soares Pereira, Antonio José de Andrade Júnior, Edla Maria Bezerra Lima, Adriana Paula da Silva Minguita, Luiz Henrique Guerreiro Rosado, Ana Paula Moreira, Antonieta Middea, Edlene Ribeiro Prudêncio, Rosa Helena Luchese, Renata Nunes Oliveira,

Microencapsulation and Drying Processes

PVA cryogels are well established as candidate biomaterials for wound healing applications but are not themselves biodegradable or antimicrobial. Blending PVA with NaCMC (CMC) or gelatin (G) can increase the gel's ability to swell and would introduce a degree of biodegradability. The incorporation of appropriate amounts of a natural antimicrobial/healing agents, such as honey (H), would contribute to the gels properties. The present work addresses the development and characterization of layered gels (PVA-H, PVA-CMC-H and PVA-G-H, with empty PVA, PVA-CMC, PVA-G gels presented as controls). The gels were characterized by FTIR, DSC, in vitro analysis of swelling and microbiological (S. aureus) effects. Addition of gelatin, NaCMC and honey to PVA diminished the PVA chains' ability to pack into crystallites. Samples containing honey swelled less and presented higher weight loss/biodegradability than samples without honey. Only the honey-laden PVA-CMC and PVA-G presented activity against S. aureus.