Produção Nacional
Revisado por pares
SARS-CoV-2 infection in patients with primary Sjögren syndrome: characterization and outcomes of 51 patients
2020; Oxford University Press; Volume: 60; Issue: 6 Linguagem: Inglês
10.1093/rheumatology/keaa748
ISSN1462-0332
AutoresPilar Brito‐Zerón, Sheila Melchor, Raphaèle Séror, Roberta Priori, Roser Solans, Belchin Kostov, Chiara Baldini, Francesco Carubbi, José Luis Callejas‐Rubio, Pablo Guisado‐Vasco, Gabriela Hernández‐Molina, Sandra Gofinet Pasoto, Valéria Valim, Antoni Sisó‐Almirall, Xavier Mariette, Patrícia Carreira, Manuel Ramos‐Casals, Stefano Bombardieri, C. Morcillo, Stefano Bombardieri, Alejandra Flores-Chávez, Manuel Ramos‐Casals, Nihan Acar‐Denizli, Ildikó Fanny Horváth, Antónia Szántó, Tünde Tarr, Raphaèle Séror, Xavier Mariette, Thomas Mandl, Peter Olsson, X. Li, Bei Xu, Chiara Baldini, Stefano Bombardieri, Jacques‐Eric Gottenberg, Saviana Gandolfo, Salvatore De Vita, Roberta Priori, Federico Giardina, Gabriela Hernández‐Molina, Jorge Sánchez‐Guerrero, Aike A. Kruize, Anneline C. Hinrichs, Valéria Valim, David Isenberg, Roser Solans, Maureen Rischmueller, Sarah Downie‐Doyle, S-K Kwok, So Hyun Park, Gunnel Nordmark, Yasunori Suzuki, Mitsuhiro Kawano, Roberto Giacomelli, Valérie Devauchelle‐Pensec, Alain Saraux, Benedikt Hofauer, Andreas Knopf, Hendrika Bootsma, Arjan Vissink, Jacques Morel, Cristina Vollenveider, Fabiola Atzeni, Soledad Retamozo, V Moça Trevisano, Berkan Armağan, Levent Kılıç, Umut Kalyoncu, Sandra Gofinet Pasoto, Belchin Kostov, Antoni Sisó‐Almirall, Sandra Consani-Fernández, Francesco Carubbi, José Luis Callejas‐Rubio, Miguel López-Dupla, R. Pérez-Álvarez, Miriam Akasbi, Pablo Guisado‐Vasco, Isabel Sánchez,
Tópico(s)Long-Term Effects of COVID-19
ResumoTo analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS.We searched for patients with primary SS presenting with SARS-CoV-2 infection (defined following and according to the European Centre for Disease Prevention and Control guidelines) among those included in the Big Data Sjögren Registry, an international, multicentre registry of patients diagnosed according to the 2002/2016 classification criteria.A total of 51 patients were included in the study (46 women, mean age at diagnosis of infection of 60 years). According to the number of patients with primary SS evaluated in the Registry (n = 8211), the estimated frequency of SARS-CoV-2 infection was 0.62% (95% CI 0.44, 0.80). All but two presented with symptoms suggestive of COVID-19, including fever (82%), cough (57%), dyspnoea (39%), fatigue/myalgias (27%) and diarrhoea (24%), and the most frequent abnormalities included raised lactate dehydrogenase (LDH) (88%), CRP (81%) and D-dimer (82%) values, and lymphopenia (70%). Infection was managed at home in 26 (51%) cases and 25 (49%) required hospitalization (five required admission to ICU, four died). Compared with patients managed at home, those requiring hospitalization had higher odds of having lymphopenia as laboratory abnormality (adjusted OR 21.22, 95% CI 2.39, 524.09). Patients with comorbidities had an older age (adjusted OR 1.05, 95% CI 1.00, 1.11) and showed a risk for hospital admission six times higher than those without (adjusted OR 6.01, 95% CI 1.72, 23.51) in the multivariate analysis.Baseline comorbidities were a key risk factor for a more complicated COVID-19 in patients with primary SS, with higher rates of hospitalization and poor outcomes in comparison with patients without comorbidities.
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