Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Low-load resistance training with blood flow restriction prevent renal function decline: The role of the redox balance, angiotensin 1–7 and vasopressin✰,✰✰

2020; Elsevier BV; Volume: 230; Linguagem: Inglês

10.1016/j.physbeh.2020.113295

1873-507X

Hugo de Luca Corrêa, Rodrigo Vanerson Passos Neves, Lysleine Alves Deus, Beatriz Maia, Áthila Teles Dantas Maya, Carmen Tzanno‐Martins, Michel Kendy Souza, José Adeirton Bezerra Silva, Anderson Sola Haro, Fernando Costa, Milton Rocha Moraes, Herbert Gustavo Simões, Jonato Prestes, Whitley J. Stone, Thiago dos Santos Rosa,

Blood Pressure and Hypertension Studies

We sought to investigate the effect of resistance training (RT) and low-load RT with moderate blood flow restriction (RT+BFR) on blood pressure, exercise pressor response, redox balance and vasoactive peptides, body composition and muscle strength in patients with stage two of chronic kidney disease (CKD). We conducted a 6-month randomized controlled exercise intervention in 90 male and female hypertensive CKD patients (58±9 years with estimated glomerular filtration rate (eGFR; of 66.1 ± 1.2 mL/kg/1.73m2). Participants were randomized to one of three groups (n = 30/group); control group (CTL), RT, and RT+BFR. RT and RT+BFR performed three weekly training sessions using similar periodization for six months (two-month mesocycles), but of different intensities. There was similarly effects between RT and RT+BFR in reducing systolic and diastolic blood pressure during daytime and 24hour period (RT: 10.4%; RT+BFR: 10.3% of decrease), fat mass, F2-isoprostanes, asymmetric dimethylarginine (ADMA) and vasopressin (p<0.05 pre-vs post). Also promoted the increase of angiotensin 1–7, nitric oxide (NO), catalase, Trolox equivalent and muscle strength (p<0.05). Both training models attenuated the decline of estimated glomerular filtration rate (p<0.0001 vs CTL). However, only RT+BFR was associated with lower discomfort during exercise (p<0.0001 pre-vs post). Statistical significance was considered with p < 0.05. These findings suggest low-load RT+BFR as a promising non-pharmacological strategy to control blood pressure, oxidative stress, vasoactive peptides, and consequently, attenuate the decrease of the eGFR.