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New Algorithms Improving PML Risk Stratification in MS Patients Treated With Natalizumab

2020; Frontiers Media; Volume: 11; Linguagem: Inglês

10.3389/fneur.2020.579438

1664-2295

Inmaculada Toboso, Amalia Tejeda Velarde, Roberto Álvarez‐Lafuente, Rafael Arroyo, Harald Hegen, Florian Deisenhammer, Susana Sainz de la Maza, José C. Álvarez‐Cermeño, Guillermo Izquierdo, Dolores Páramo, Pedro de la Oliva, Bonaventura Casanova, Eduardo Agüera, Diego Franciotta, Matteo Gastaldi, Óscar Fernández, Patricia Urbaneja, José Manuel García‐Domínguez, F. Romero, Alicia Laroni, Antonio Uccelli, Ángel Pérez Sempere, Albert Saiz, Yolanda Blanco, Daniela Galimberti, Elio Scarpini, Carmen Espejo, Xavier Montalbán, Ludwig Rasche, Friedemann Paul, Inés González‐Suarez, Elena Álvarez, Cristina Ramo‐Tello, Ana B. Caminero, Yolanda Aladro, Carmen Calles, Pablo Eguía, Antonio Belenguer, Lluís Ramió‐Torrentà, Ester Quintana, José Rodríguez, Agustı́n Oterino, Carlos López de Silanes, Luis I. Casanova, Lamberto Landete, Jette Lautrup Frederiksen, Gabriel Bsteh, Patricia Mulero, Manuel Comabella, Miguel Ángel Hernández, Mercedes Espiño, José M. Prieto, D. Robles Pérez, María Otaño, Francisco Carrillo Padilla, J.A. García-Merino, Laura Navarro-Cantó, Alfonso Muriel, Lucienne Costa Frossard, Luisa María Villar,

Herpesvirus Infections and Treatments

Overview: We assessed the role of age and disease activity as new factors contributing to establish the risk of progressive multifocal leucoencephalopathy in multiple sclerosis patients treated with natalizumab in 36 University Hospitals in Europe. We performed the study in 1,307 multiple sclerosis patients (70.8% anti-John Cunninghan virus positive antibodies) treated with natalizumab for a median time of 3.28 years. Epidemiological, clinical, and laboratory variables were collected. Lipid-specific IgM oligoclonal band status was available in 277 patients. Factors associated with progressive multifocal leucoencephalopathy onset were explored by uni- and multivariate logistic regression. Results: Thirty-five patients developed progressive multifocal leucoencephalopathy. The multivariate analysis identified anti-John Cunninghan virus antibody indices and relapse rate as the best predictors for the onset of this serious opportunistic infection in the whole cohort. They allowed to stratify progressive multifocal leucoencephalopathy risk before natalizumab initiation in individual patients [area under the curve (AUC) = 0.85]. The risk ranged from <1/3,300 in patients with anti-John Cunninghan virus antibody indices <0.9 and relapse rate >0.5, to 1/50 in the opposite case. In patients with lipid-specific IgM oligoclonal bands assessment, age at natalizumab onset, anti-John Cunninghan virus antibody indices, and lipid-specific IgM oligoclonal band status predicted progressive multifocal leucoencephalopathy risk (AUC = 0.92). The absence of lipid-specific IgM oligoclonal bands was the best individual predictor (OR = 40.94). The individual risk ranged from <1/10,000 in patients younger than 45 years at natalizumab initiation, who showed anti John Cunningham virus antibody indices <0.9 and lipid-specific IgM oligoclonal bands to 1/33 in the opposite case. Conclusions: In a perspective of personalized medicine, disease activity, anti-lipid specific IgM oligoclonal bands, anti Jonh Cunninghan virus antibody levels, and age can help tailor natalizumab therapy in multiple sclerosis patients, as predictors of progressive multifocal leucoencephalopathy.