Early-life stress induces the development of Alzheimer's disease pathology via angiopathy
2020; Elsevier BV; Volume: 337; Linguagem: Inglês
10.1016/j.expneurol.2020.113552
ISSN1090-2430
AutoresTomoko Tanaka, Shinobu Hirai, Masato Hosokawa, Takashi Saito, Hiroshi Sakuma, Takaomi C. Saido, Masato Hasegawa, Haruo Okado,
Tópico(s)Neurological Disorders and Treatments
ResumoAlzheimer's disease (AD), a progressive neurodegenerative disorder, is a major societal, scientific, and economic problem. Several early-life factors associated with an increased risk for the clinical diagnosis of AD have recently been identified. In the present study, we investigated the involvement of early-life stress in the pathogenesis of AD using heterozygous amyloid precursor protein (APP) mutant mice (App
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