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Exercise and pyridostigmine prevents gastric emptying delay and increase blood pressure and cisplatin-induced baroreflex sensitivity in rats

2020; Elsevier BV; Volume: 267; Linguagem: Inglês

10.1016/j.lfs.2020.118972

1879-0631

Mariana Sousa Silva, Yasmim de Andrade Gomes, Mickael Laudrup de Sousa Cavalcante, Pedro Victor Nogueira Telles, Alda Cássia Alves da Silva, Juliana Soares Severo, Raísa de Oliveira Santos, Brenda Lois Barros dos Santos, Gisele Lopes Cavalcante, Cláudio Henrique Lima Rocha, Raimundo C. Palheta, Rita de Cássia Meneses Oliveira, Rosimeire Ferreira dos Santos, João Paulo J. Sabino, Armênio Aguiar dos Santos, Moisés Tolentino Bento da Silva,

Circadian rhythm and melatonin

Cisplatin treatment induces an autonomic dysfunction and gastrointestinal and cardiovascular disorders. Physical exercise as well as pyridostigmine treatment induces improves in the autonomic nervous system. In the current study, we investigated the effect of physical exercise and pyridostigmine treatment on gastrointestinal and cardiovascular changes in cisplatin-treated rats. Rats were divided into groups: Saline (S), Cisplatin (Cis), Exercise (Ex), Cisplatin+Exercise (Cis+Ex), Pyridostigmine (Pyr), and Cisplatin+Pyridostigmine (Cis+Pyr). We induced gastrointestinal dysmotility by administering 3 mg kg