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BIBTEX RIS

Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model

2020; Multidisciplinary Digital Publishing Institute; Volume: 22; Issue: 1 Linguagem: Inglês

10.3390/ijms22010364

ISSN

1661-6596

Autores

Qiyuan Han, Thomas J. Y. Kono, Charles G. Knutson, N. Parry, Christopher L. Seiler, James G. Fox, Steven R. Tannenbaum, Natalia Tretyakova,

Tópico(s)

Cytokine Signaling Pathways and Interactions

Resumo

Epigenetic dysregulation is hypothesized to play a role in the observed association between inflammatory bowel disease (IBD) and colon tumor development. In the present work, DNA methylome, hydroxymethylome, and transcriptome analyses were conducted in proximal colon tissues harvested from the

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