Phenotypic Mapping of Pathologic Cross-Talk between Glioblastoma and Innate Immune Cells by Synthetic Genetic Tracing
2020; American Association for Cancer Research; Volume: 11; Issue: 3 Linguagem: Inglês
10.1158/2159-8290.cd-20-0219
ISSN2159-8290
AutoresMatthias Jürgen Schmitt, Carlos Company, Yuliia Dramaretska, Iros Barozzi, Andreas Göhrig, Sonia Kertalli, Melanie Großmann, Heike Naumann, María Pilar Sánchez-Bailón, Danielle Hulsman, Rainer Glaß, Massimo Squatrito, Michela Serresi, Gaetano Gargiulo,
Tópico(s)interferon and immune responses
ResumoGlioblastoma is a lethal brain tumor that exhibits heterogeneity and resistance to therapy. Our understanding of tumor homeostasis is limited by a lack of genetic tools to selectively identify tumor states and fate transitions. Here, we use glioblastoma subtype signatures to construct synthetic genetic tracing cassettes and investigate tumor heterogeneity at cellular and molecular levels,
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