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TransPrEP: Results from the Pilot Study of a Social Network-Based Intervention to Support PrEP Adherence Among Transgender Women in Lima, Peru

2021; Springer Science+Business Media; Volume: 25; Issue: 6 Linguagem: Inglês

10.1007/s10461-020-03117-4

1573-3254

Jesse L. Clark, Sari L. Reisner, Amaya Perez‐Brumer, Leyla Huerta, Hugo Sánchez, Kathleen Moriarty, Maria Mamani Luque, Hideaki Okochi, Ximena Salazar, Matthew J. Mimiaga, Jorge Sánchez, Monica Gandhi, Kenneth H. Mayer, Javier R. Lama,

Sex work and related issues

We conducted a pilot randomized controlled trial of a social network-based intervention to promote PrEP adherence among transgender women (TW) in Lima, Peru. We enrolled 89 TW from six social networks and cluster-randomized them 1:1 to standard of care (n = 44) or the TransPrEP intervention (n = 45). Core workshops discussed strategies to support PrEP adherence and defined group adherence objectives. Maintenance workshops discussed participants’ experiences taking PrEP and collective adherence goals. At 3-month follow-up, we evaluated 40 participants and obtained 29 hair samples for tenofovir level measurements. Though no significant differences were observed, 36.4% (4/11) of participants of TransPrEP participants and 10.0% (1/10) of control participants had tenofovir levels > 0.023 ng/mg, consistent with ≥ 4 doses per week. 81.8% (9/11) of intervention and 40.0% (4/10) of control participants had any detectable tenofovir in their hair. Pilot assessment of our network-based intervention suggested a trend towards improved PrEP adherence, measured objectively, for TW in Peru.