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Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China

2020; Centers for Disease Control and Prevention; Volume: 27; Issue: 1 Linguagem: Inglês

10.3201/eid2701.201543

1080-6059

K.S. Leung, Timothy Ting-Leung Ng, Alan Wu, Miranda Chong-Yee Yau, Hiu-Yin Lao, Ming-Pan Choi, Kingsley King-Gee Tam, Lam-Kwong Lee, Barry K. C. Wong, Alex Yat Man Ho, K. T. Yip, Kwok-Cheung Lung, Raymond Wai-To Liu, Eugene Yuk-Keung Tso, Wai-Shing Leung, Man-Chun Chan, Yuk-Yung Ng, Kit-Man Sin, Kitty Sau-Chun Fung, Sandy Ka-Yee Chau, Wing‐Kin To, Tak-Lun Que, David Shum, Shea Ping Yip, Wing Cheong Yam, G. G. Siu,

Animal Virus Infections Studies

Abstract Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10−3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.