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Viral targets for vaccines against COVID-19

2020; Nature Portfolio; Volume: 21; Issue: 2 Linguagem: Inglês

10.1038/s41577-020-00480-0

1474-1741

Lianpan Dai, George F. Gao,

Vaccine Coverage and Hesitancy

Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19) pandemic and to help the return to pre-pandemic normalcy. A great many vaccine candidates are being developed, several of which have completed late-stage clinical trials and are reporting positive results. In this Progress article, we discuss which viral elements are used in COVID-19 vaccine candidates, why they might act as good targets for the immune system and the implications for protective immunity. As the world races to develop vaccines against SARS-CoV-2, Dai and Gao highlight which viral targets are best to include in a vaccine and how this impacts the induced immune response and, ultimately, the safety and efficacy of a vaccine.