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Is it Safe to Be Transplanted From Living Donors Who Recovered From COVID-19? Experience of 31 Kidney Transplants in a Multicenter Cohort Study From India

2020; Wolters Kluwer; Volume: 105; Issue: 4 Linguagem: Inglês

10.1097/tp.0000000000003609

1534-6080

Vivek Kute, Suraj Godara, Sandeep Guleria, Deepak Shankar Ray, Feroz Aziz, Umapati Hegde, Ashish Sharma, K.S. Nayak, Vishwanath Siddini, Piyali Sarkar, Sharmila Thukral, Rabi Ranjan Sow Mondal, Jitendra Goswami, Himanshu V. Patel, Abi Abraham M, Vivek Pathak, Urmila Anandh, Pranaw Kumar Jha, Suhas Bavikar, Ravi Shankar Bonu, Sanjeev Gulati, Anil Kumar, Dinesh Kumar Yadav,

COVID-19 Impact on Reproduction

There is lack of data on feasibility and safety of kidney transplants from living donors who recovered from COVID-19.Here, we present a retrospective cohort study of 31 kidney transplant recipients (KTR) from living donors who recovered from polymerase chain reaction confirmed COVID-19 across 19 transplant centers in India from July 3, 2020, to December 5, 2020. We detailed demographics, clinical manifestations, immunosuppression regimen, treatment, and outcomes. Donors with a previous diagnosis of COVID-19 were accepted after documenting 2 negative polymerase chain reaction tests with complete symptom resolution for at least 28 days and significant social distancing for 14 days before surgery.COVID-19 clinical severity in donors ranged from completely asymptomatic (71%, n = 22) to mild infection (29%, n = 9). None progressed to moderate or severe stages of the disease in the entire clinical course of home treatment. Patient and graft survival was 100%, respectively, with acute cellular rejection being reported in 6.4% (n = 2) recipient. All recipients and donors were asymptomatic with normal creatinine at median follow-up of 44 days after surgery without any complications relating to surgery and COVID-19.Our data support safety of proceeding with living donation for asymptomatic individuals with comprehensive donor, recipients screening before surgery, using a combination of clinical, radiologic, and laboratory criteria. It could provide new insights into the management of KTR from living donors who have recovered from COVID-19 in India. To the best of our knowledge, this remains the largest cohort of KTR from living donors who recovered from COVID-19.