Portal de Periódicos da CAPES

Protective effect of the polyherbal formulation, Nalpamaram against ethanol induced hepatotoxicity in rats

2020; Volume: 9; Issue: 2 Linguagem: Inglês

10.21276/ap.2020.9.2.21

2393-9885

S. Jyothilekshmi, A K Valsa, Ramadasan Kuttan,

Drug-Induced Hepatotoxicity and Protection

Nalpamaram which constitutes a group of four plants, Ficus racemosa, Ficus microcarpa, Ficus benghalensis and Ficus religiosa is one of the polyherbal formulations, used by ayurvedic practitioners for the treatment of a variety of health problems.In the present study, the hepatoprotective activity of aqueous extract of the barks of Nalpamaram (NMAE) against ethanol induced hepatotoxicity was studied in male albino rats.The levels of the toxicity marker enzymes aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and bilirubin showed a significant increase in the ethanol treated group indicating liver injury.On treatment with NMAE at various concentrations, the activity of the enzymes AST, ALT, ALP and GGT, and total bilirubin significantly decreased compared to the ethanol treated group.The total protein and albumin levels increased on treatment with NMAE.The hepatoprotective activity was also supported by the histopathological studies of the liver tissue.The effects of NMAE at a dose of 500 mg/kg b.wt/day were comparable to that of the standard drug silymarin.