Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer
2021; American Association for the Advancement of Science; Volume: 14; Issue: 664 Linguagem: Inglês
10.1126/scisignal.abc4436
ISSN1937-9145
AutoresDaniel R. Crooks, Nunziata Maio, Martin Lang, Christopher J. Ricketts, Cathy D. Vocke, Sandeep Gurram, Sevilay Turan, Yunyoung Kim, Geetha Mariah Cawthon, Ferri Sohelian, Natalia de Val, Ruth M. Pfeiffer, Parthav Jailwala, Mayank Tandon, Bao Tran, Teresa W.‐M. Fan, Andrew N. Lane, Thomas Ried, Darawalee Wangsa, Ashkan A. Malayeri, Maria J. Merino, Youfeng Yang, Jordan L. Meier, Mark W. Ball, Tracey A. Rouault, Ramaprasad Srinivasan, W. Marston Linehan,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoKidney tumors lacking fumarate hydratase become aggressive due to a metabolic shift arising from altered mitochondrial DNA.
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