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Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

2021; Multidisciplinary Digital Publishing Institute; Volume: 22; Issue: 2 Linguagem: Inglês

10.3390/ijms22020634

1661-6596

Giuseppe Venturella, Valeria Ferraro, Fortunato Cirlincione, Maria Letizia Gargano,

Medicinal Plants and Bioactive Compounds

Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical studies are reported in this review. Besides, we analyzed the therapeutic use and pharmacological activities of mushrooms.