Artigo Acesso aberto Produção Nacional Revisado por pares

Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes

2021; American Chemical Society; Volume: 84; Issue: 1 Linguagem: Inglês

10.1021/acs.jnatprod.0c01069

ISSN

1520-6025

Autores

Meri Emili F. Pinto, Lai Yue Chan, Johannes Koehbach, Seema Devi, Carsten Gründemann, Christian W. Gruber, Mário Gomes, Vanderlan da Silva Bolzani, Eduardo Maffud Cilli, David J. Craik,

Tópico(s)

Toxin Mechanisms and Immunotoxins

Resumo

Cyclotides are plant-derived peptides found within five families of flowering plants (Violaceae, Rubiaceae, Fabaceae, Solanaceae, and Poaceae) that have a cyclic backbone and six conserved cysteine residues linked by disulfide bonds. Their presence within the Violaceae species seems ubiquitous, yet not all members of other families produce these macrocyclic peptides. The genus

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