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Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders Along the Impulsivity-Compulsivity Spectrum

2021; Elsevier BV; Volume: 90; Issue: 5 Linguagem: Inglês

10.1016/j.biopsych.2020.12.028

1873-2402

Zhiyu Yang, Hanrui Wu, Phil H. Lee, Fotis Tsetsos, Lea K. Davis, Dongmei Yu, Sang Lee, Søren Dalsgaard, Jan Haavik, Csaba Barta, Tetyana Zayats, Valsamma Eapen, Naomi R. Wray, Bernie Devlin, Mark J. Daly, Benjamin M. Neale, Anders D. Børglum, James J. Crowley, Jeremiah M. Scharf, Carol A. Mathews, Stephen V. Faraone, Barbara Franke, Manuel Mattheisen, Jordan W. Smoller, Peristera Paschou,

Genetic Associations and Epidemiology

Tourette syndrome (TS) is often found comorbid with other neurodevelopmental disorders across the impulsivity-compulsivity spectrum, with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) as most prevalent. This points to the possibility of a common etiological thread along an impulsivity-compulsivity continuum.