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Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women

2021; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 1 Linguagem: Inglês

10.3390/v13010112

1999-4915

M. Cruz‐Lemini, Elena Perez, María Luisa de la Cruz, África Caño Aguilar, María Encinas Pardilla, Pilar Prats, Marta Muner-Hernando, Laura Forcén Acebal, Pilar Pintado Recarte, María del Carmen Medina Mallen, Noelia Pérez Pérez, Judit Canet Rodríguez, Ana Villalba Yarza, Olga Nieto Velasco, Pablo Del Barrio Fernández, Carmen Lago, Beatriz Marcos Puig, Begoña Muñoz Abellana, Laura Fuentes Ricoy, Àgueda Rodríguez Vicente, Maria Janeiro Freire, Macarena Alférez Álvarez-Mallo, Cristina Casanova Pedraz, Onofre Alomar Mateu, Cristina Lesmes Heredia, Juan Wizner de Alva, Alma Posadas San Juan, Montserrat Macia Badia, Cristina Álvarez Colomo, Antonio Sánchez Muñoz, Laia Pratcorona, Rubén Alonso Saiz, M. López Rodríguez, Maria Barbancho Lopez, Marta Meca Casbas, Óscar Vaquerizo Ruiz, Eva Morán Antolín, Maria Nuñez Valera, Camino Fernández, A. Tubau, Alejandra Cano García, Susana Soldevilla Pérez, Irene Gattaca Abasolo, José Adanez García, Alberto Puertas Prieto, Rosa Serna, Maria Guadix Martin, Mónica Catalina Coello, Silvia Espuelas Malón, José Antonio Sainz‐Bueno, Maria Granell Escobar, Sara Cruz Melguizo, Óscar Martínez Pérez,

COVID-19 and healthcare impacts

Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13–3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.