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Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson’s Disease

2021; Elsevier BV; Volume: 132; Issue: 3 Linguagem: Inglês

10.1016/j.clinph.2021.01.001

1872-8952

Alberto Jaramillo‐Jimenez, Jazmín Ximena Suárez-Revelo, John Fredy Ochoa Gómez, Jairo Alexander Carmona Arroyave, Yamile Bocanegra, Francisco Lopera, Omar Buriticá, David Antonio Pineda-Salazar, Leonardo Moreno Gómez, Carlos Tobón, Miguel Germán Borda, Laura Bonanni, Dominic ffytche, Kolbjørn Brønnick, Dag Aarsland,

Parkinson's Disease Mechanisms and Treatments

To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson's Disease (PD) non-demented patients. 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-state quantitative electroencephalogram (qEEG). Correlations between α/θ and performance in several neuropsychological tests were conducted, significant findings were included in a moderation analysis. The α/θ in all regions was lower in PD than in HC, with larger effect sizes in the posterior regions. Right parietal, and right and left occipital α/θ had significant positive correlations with performance in Judgement of Line Orientation Test (JLOT) in PD. Adjusted moderation analysis indicated that right, but not left, occipital α/θ influenced the JLOT performance related to PD. Reduction of the occipital α/θ, in particular on the right side, was associated with visuospatial performance impairment in PD. Visuospatial impairment in PD, which is highly correlated with the subsequent development of dementia, is reflected in α/θ in the right posterior regions. The right occipital α/θ may represent a useful qEEG marker for evaluating the presence of early signs of cognitive decline in PD and the subsequent risk of dementia.