Portal de Periódicos da CAPES

SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency

2021; Elsevier BV; Volume: 224; Linguagem: Inglês

10.1016/j.clim.2020.108662

1521-7035

Nicolai S. C. van Oers, Natasha W. Hanners, Paul K. Sue, Victor Aquino, Quan‐Zhen Li, John W. Schoggins, Christian Wysocki,

Immunodeficiency and Autoimmune Disorders

X-linked severe combined immunodeficiency (X-SCID) is a disorder of adaptive immunity caused by mutations in the IL-2 receptor common gamma chain gene resulting in deficiencies of T and natural killer cells, coupled with severe dysfunction in B cells. X-SCID is lethal without allogeneic stem cell transplant or gene therapy due to opportunistic infections. An infant with X-SCID became infected with SARS-CoV-2 while awaiting transplant. The patient developed severe hepatitis without the respiratory symptoms typical of COVID-19. He was treated with convalescent plasma, and thereafter was confirmed to have SARS-CoV-2 specific antibodies, as detected with a microfluidic antigen array. After resolution of the hepatitis, he received a haploidentical CD34 selected stem cell transplant, without conditioning, from his father who had recovered from COVID-19. SARS CoV-2 was detected via RT-PCR on nasopharyngeal swabs until 61 days post transplantation. He successfully engrafted donor T and NK cells, and continues to do well clinically.