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The common and mutual exclusive interactome of the oncogenes YAP and TAZ in liver cancer

2021; Thieme Medical Publishers (Germany); Linguagem: Inglês

10.1055/s-0040-1722050

1439-7803

Marie C. Wesener, Sabine Merker, Barbara Helm, L Thiess, Ursula Klingmüller, Thomas Ruppert, Peter Schirmacher, Kai Breuhahn, S Weiler,

Hippo pathway signaling and YAP/TAZ

The Hippo pathways effectors yes-associated protein (YAP) and WW domain containing transcription regulator 1 (WWTR1; syn: TAZ) play an important role in tumor development and progression. Recent findings illustrate that both oncogenes facilitate their pro-tumorigenic properties in liver cancer via common and exclusive mechanisms. However, the underlying molecular network of YAP- and TAZ-induced tumorigenesis is not fully understood. Here, we aim to dissect their respective interactome in liver cancer cells.