Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension
2021; American Physical Society; Volume: 320; Issue: 3 Linguagem: Inglês
10.1152/ajpheart.00520.2020
ISSN1522-1539
AutoresWilliam Mundo, Gabriel H. Wolfson, Lorna G. Moore, Julie A. Houck, Do Park, Colleen G. Julian,
Tópico(s)Renal and related cancers
ResumoPerinatal hypoxia induces permanent structural and functional changes in the lung and its pulmonary circulation that are associated with the development of pulmonary hypertension (PH) in later life. The mechanistic target of the rapamycin (mTOR) pathway is vital for fetal lung development and is implicated in hypoxia-associated PH, yet its involvement in the developmental programming of PH remains unclear. Pregnant C57/BL6 dams were placed in hyperbaric (760 mmHg) or hypobaric chambers during gestation (505 mmHg,
Referência(s)