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Dual‐Targeting Peptide‐Guided Approach for Precision Delivery and Cancer Monitoring by Using a Safe Upconversion Nanoplatform

2021; Wiley; Volume: 8; Issue: 5 Linguagem: Inglês

10.1002/advs.202002919

2198-3844

Shuai Zha, Ho‐Fai Chau, Wai Yin Chau, Lai Sheung Chan, Jun Lin, Kwok Wai Lo, William C. Cho, Yim Ling Yip, Sai Wah Tsao, Paul J. Farrell, Liang Feng, Jin Ming Di, Ga‐Lai Law, Hong Lok Lung, Ka‐Leung Wong,

Luminescence and Fluorescent Materials

Using Epstein-Barr virus (EBV)-induced cancer cells and HeLa cells as a comparative study model, a novel and safe dual-EBV-oncoproteins-targeting pH-responsive peptide engineering, coating, and guiding approach to achieve precision targeting and treatment strategy against EBV-associated cancers is introduced. Individual functional peptide sequences that specifically bind to two overexpressed EBV-specific oncoproteins, EBNA1 (a latent cellular protein) and LMP1 (a transmembrane protein), are engineered in three different ways and incorporated with a pH-sensitive tumor microenvironment (TME)-cleavable linker onto the upconversion nanoparticles (UCNP) NaGdF