Portal de Periódicos da CAPES

A New SARS-CoV-2 Dual-Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection

2021; American Society for Microbiology; Volume: 59; Issue: 4 Linguagem: Inglês

10.1128/jcm.02438-20

1098-660X

Sean C. Taylor, Beth Hurst, Carmen Charlton, Ashley Bailey, Jamil N. Kanji, Mary K. McCarthy, Thomas E. Morrison, Leah Huey, Kyle Annen, Melkon DomBourian, Vijaya Knight,

COVID-19 Clinical Research Studies

Many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology tests have proven to be less accurate than expected and do not assess antibody function as neutralizing, correlating with protection from reinfection. A new assay technology measuring the interaction of the purified SARS-CoV-2 spike protein receptor binding domain (RBD) with the extracellular domain of the human angiotensin-converting enzyme 2 (hACE2) receptor detects these important antibodies.