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A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group

2021; SAGE Publishing; Volume: 30; Issue: 4 Linguagem: Inglês

10.1177/0961203320988586

1477-0962

José A. Gómez‐Puerta, Guillermo J. Pons‐Estel, Rosana Quintana, Romina Nieto, Rosa Maria Serrano Morales, Guillermina Harvey, Daniel Wojdyla, Marina Scolnik, Carmen Funes Soaje, Paula Alba Moreyra, Elisa Novatti, Fernando Arizpe, Guillermo Berbotto, Luciana González Lucero, Sabrina Porta, Nicolás Pérez, Anabella M Rodriguez, Simone Appenzeller, Ana Carolina de Oliveira e Silva Montadon, Odirlei André Monticielo, Fernando Cavalcanti, Francinne Machado Ribeiro, Eduardo Ferreira Borba, Edgard Torres dos Reis-Neto, Óscar Neira, José Miguel Chahuán, Milena Mimica, Gustavo Aroca, Gabriel J. Tobón, Gloria Vásquez, Gerardo Quintana-López, Mario José Moreno Álvarez, Miguel Ángel Saavedra, Mario Pérez Cristóbal, Hilda Fragoso-Loyo, Luís M. Amezcua‐Guerra, Yelitza González-Bello, Carlos Abud‐Mendoza, Jorge Antonio Esquivel‐Valerio, Margarita Duarte, I. Acosta-Colman, Claudia S Mora-Trujillo, Cristina Reátegui-Sokolova, Armando A Calvo Quiroz, Roberto Muñoz-Louis, Ernesto Cairoli, Iliana Rosas, Martín Rebella, Mario H. Cardiel, Ignacio García‐De La Torre, Luís J. Catoggio, Graciela S. Alarcón, Bernardo A. Pons‐Estel, Guillermo J. Pons‐Estel, José A. Gómez‐Puerta, Bernardo A. Pons‐Estel, Diana Fernández-Ávila, Enrique R. Soriano, Nidia Meras, Gisela Subilis, L. Maurelli, Alejandra Babini, Carla Gobbi, Cintia Otaduy, María Haye Salinas, Verónica Saurit, Valeria Arturi, Mercedes García, M. Emilia Sattler, Julieta A. Daniele, M. C. Bertolaccini, Verónica Bellomio, Marina Micelli, Carla Matellán, Eduardo Kerzberg, María de los Ángeles Gargiulo, Graciela Gómez, Cecilia Pisoni, M. Cosatti, Lílian Tereza Lavras Costallat, Ana Carolina Londe, Vitalina de Souza Barbosa, Nilzio A Da Silva, Andrese Aline Gasparin, João Carlos Tavares Brenol, Fernando Schmidt Fernandes, Ricardo Machado Xavier, Ângela Luzia P Duarte, Henrique Ataíde Mariz, Carolina Albanez A. Cunha Andrade, Evandro Mendes Klumb, Eloísa Bonfá, Luciana Parente Costa Seguro, Emily Figueiredo Neves Yuki, Lucas Victória de Oliveira Martins, Emília Inoue Sato, Iris Guerra, Alexis Peralta, Carolina Llanos, Paula I. Burgos, Loreto Massardo, Lizeth de la Hoz, Andrés Cadena Bonfanti, Antonio Iglesias Gamarra, Eduardo Egea, Ivana Nieto‐Aristizábal, Alex Echeverri, Luis Alonso González, Mauricio Restrepo‐Escobar, Rafael López‐Martínez, José M. Martínez Pérez, Andrés Vera, Luis J. Jara, Olga Vera‐Lastra, Reyna Elizabeth Sánchez-Briones, Margarita Portela Hernández, Eduardo Martín‐Nares, Carlos Nuñez Alvarez, Luis H. Silveira, Yaneli Juárez-Vicuña, Itzel Viridiana Reyes‐Pérez, Ignacio García-Valladares, Alejandra Pérez-Santana, Marcela Fandiño, Enrique Cuevas-Orta, Andrea Moreno-Salinas, D. Á. Galarza-Delgado, Jhonatan Losanto, Patricia Langjahr, Marcos Vázquez, Astrid Paats, Jorge Cieza-Calderón, Magaly Alva, Wilkerson Pérez Medina, Manuel F. Ugarte‐Gil, Rocío V. Gamboa‐Cárdenas, Risto Perich-Campos, Katiuzka Zuñiga Corrales, Norman Valdivia Paredes, Yannet Mendoza Quispe, Daniel Ccolcca Huaman, María Mimbela Caballero, Edral Rodríguez-Bautista, Rafael Alba Feriz, Ricardo Robaina, Andrea Quadrelli Sánchez, Darwin Cordovilla, Andréa Maria Duarte Vargas, Ana Carolina Vargas, Alejandro Fernández, Anthony Henry, A. Castañeyra Perdomo, Gonzalo Silveira, Álvaro Danza, Carina Pizarrosa, Adriana Carlomagno,

Renal Diseases and Glomerulopathies

Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.