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Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family

2021; Multidisciplinary Digital Publishing Institute; Volume: 26; Issue: 3 Linguagem: Inglês

10.3390/molecules26030564

ISSN

1433-1373

Autores

Nayara Simas Frauches, Júlia Montenegro, Thuane Amaral, Joel Pimentel de Abreu, Gabriela Laiber, Jorge Junior, Renata Galhardo Borguini, Manuela Cristina Pessanha de Araújo Santiago, Sidney Pacheco, Vânia Mayumi Nakajima, Ronoel Luiz de Oliveira Godóy, Anderson Junger Teodoro,

Tópico(s)

Essential Oils and Antimicrobial Activity

Resumo

There is a significant indication of the beneficial health effects of fruit rich diets. Fruits of native plant species have noticeably different phytochemicals and bioactive effects. The aim of this work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ), jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and their influence on antioxidant activity in vitro and antiproliferative effects on human colon adenocarcinoma cells. According to the results, dried peel powders (DP) have a high anthocyanin content, phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD). M. jaboticaba dried peel powder extract had a higher total anthocyanin and phenolic compounds content (802.90 ± 1.93 and 2152.92 ± 43.95 mg/100 g, respectively). A reduction in cell viability of HT-29 cells after treatment with M. jaboticaba extracts (DP-MJ and FD-MJ) was observed via MTT assay. Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SM had an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cells in relation to the control group. The findings of this study highlight the potential of peel powders from Myrtaceae fruits as an important source of natural antioxidants and a protective effect against colon adenocarcinoma.

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