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Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch School‐Age Children

2021; Wiley; Volume: 29; Issue: 2 Linguagem: Inglês

10.1002/oby.23082

1930-739X

Carolina C. V. Silva, Vincent W. V. Jaddoe, Chalana M. Sol, Hanan El Marroun, María Pilar Santamaría Martínez, Kurunthachalam Kannan, Leonardo Trasande, Susana Santos,

Effects and risks of endocrine disrupting chemicals

Objective The purpose of this study was to investigate the associations of urinary phthalates and bisphenols at age 6 years old with body fat and cardiovascular risk factors at 6 and 10 years and with the change from 6 to 10 years. Methods Among 471 Dutch children, the phthalates and bisphenols urinary concentrations at 6 years and BMI, fat mass index, android fat mass, blood pressure, glucose, insulin, and lipids blood concentrations at 6 and 10 years were measured. Results An interquartile range increase in di‐ n ‐octyl phthalate (DNOP) metabolites concentrations at 6 years was associated with an increased risk of overweight at 6 and 10 years (odds ratio: 1.44; 95% CI: 1.11‐1.87, and 1.43; 95% CI: 1.09‐1.86, respectively). Also, higher DNOP metabolites concentrations were associated with higher fat mass index at 6 years, higher systolic blood pressure at 10 years, a decrease in high‐density lipoprotein cholesterol, and an increase in triglycerides concentrations from 6 to 10 years ( P < 0.05). Higher total bisphenols and bisphenol A concentrations were associated with a decrease in BMI from 6 to 10 years ( P < 0.01). Conclusions DNOP metabolites are associated with overweight and an adverse cardiovascular profile in childhood. Total bisphenols and bisphenol A are associated with a decrease in BMI from 6 to 10 years.