Artigo Revisado por pares

Novel Strategies in the War Against Antibiotic Resistance

2021; Future Science Ltd; Volume: 13; Issue: 6 Linguagem: Inglês

10.4155/fmc-2021-0009

ISSN

1756-8927

Autores

Stella Cascioferro, Barbara Parrino, Daniela Carbone, Camilla Pecoraro, Patrizia Diana,

Tópico(s)

Cancer therapeutics and mechanisms

Resumo

Future Medicinal ChemistryVol. 13, No. 6 EditorialNovel strategies in the war against antibiotic resistanceStella Cascioferro, Barbara Parrino, Daniela Carbone, Camilla Pecoraro & Patrizia DianaStella Cascioferro https://orcid.org/0000-0002-4725-1881Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy, Barbara Parrino https://orcid.org/0000-0003-0163-1579Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy, Daniela Carbone https://orcid.org/0000-0001-5969-7023Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy, Camilla Pecoraro https://orcid.org/0000-0002-6854-0551Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy & Patrizia Diana *Author for correspondence: E-mail Address: patrizia.diana@unipa.ithttps://orcid.org/0000-0002-4883-2004Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, ItalyPublished Online:20 Jan 2021https://doi.org/10.4155/fmc-2021-0009AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: antibiotic resistanceantivirulence strategybiofilmDsbAMRSAReferences1. Blair JMA, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJV. Molecular mechanisms of antibiotic resistance. Nat. Rev. Microbiol. 13(1), 42–51 (2015).Crossref, Medline, CAS, Google Scholar2. Parrino B, Carbone D, Cirrincione G, Diana P, Cascioferro S. Inhibitors of antibiotic resistance mechanisms: clinical applications and future perspectives. Future Med. Chem. 12(5), 357–359 (2020).Link, CAS, Google Scholar3. Cascioferro S, Parrino B, Carbone D et al. Thiazoles, their benzofused systems, and thiazolidinone derivatives: versatile and promising tools to combat antibiotic resistance. J. Med. Chem. 63(15), 7923–7956 (2020).Crossref, Medline, CAS, Google Scholar4. Parrino B, Schillaci D, Carnevale I et al. Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance. Eur. J. Med. Chem. 161, 154–178 (2019).Crossref, Medline, CAS, Google Scholar5. Carbone A, Cascioferro S, Parrino B et al. Thiazole analogues of the marine alkaloid nortopsentin as inhibitors of bacterial biofilm formation. Molecules 26, 81 (2021).Crossref, CAS, Google Scholar6. Parrino B, Carbone D, Cascioferro S et al. 1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A. Eur. J. Med. Chem. 209, 112892 (2021).Crossref, Medline, CAS, Google Scholar7. Cascioferro S, Parrino B, Petri GL et al. 2,6-Disubstituted imidazo[2,1-b] [1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors. Eur. J. Med. Chem. 167, 200–210 (2019).Crossref, Medline, CAS, Google Scholar8. Carbone A, Parrino B, Cusimano MG et al. New thiazole nortopsentin analogues inhibit bacterial biofilm formation. Mar. Drugs 16(8), 274 (2018).Crossref, Google Scholar9. Parrino B, Diana P, Cirrincione G, Cascioferro S. Bacterial biofilm inhibition in the development of effective anti-virulence strategy. Open J. Med. Chem. 12(1), 84–87 (2018).Crossref, Google Scholar10. Cascioferro S, Carbone D, Parrino B et al. Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm-associated infections. ChemMedChem 15, 1–17 (2020).Google Scholar11. Hassoun A, Linden PK, Friedman B. Incidence, prevalence, and management of MRSA bacteremia across patient populations – a review of recent developments in MRSA management and treatment. Crit. Care 21 (1), 211 (2017).Crossref, Medline, Google Scholar12. Lim D, Strynadka NCJ. Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat. Struct. Biol. 9(11), 870–876 (2002).Medline, CAS, Google Scholar13. Garrison AT, Bai F, Abouelhassan Y, Paciaroni NG, Jin S, Iii RWH. Bromophenazine derivatives with potent inhibition, dispersion and eradication activities against Staphylococcus aureus biofilms. RSC Adv. 5(2), 1120–1124 (2014).Crossref, Google Scholar14. Garrison AT, Abouelhassan Y, Norwood VM et al. Structure–activity relationships of a diverse class of halogenated phenazines that targets persistent, antibiotic-tolerant bacterial biofilms and Mycobacterium tuberculosis. J. Med. Chem. 59(8), 3808–3825 (2016).Crossref, Medline, CAS, Google Scholar15. Dickey SW, Cheung GYC, Otto M. Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat. Rev. Drug Discov. 16(7), 457–471 (2017).Crossref, Medline, CAS, Google Scholar16. Totsika M, Vagenas D, Paxman JJ et al. Inhibition of diverse DsbA enzymes in multi-DsbA encoding pathogens. Antioxid. Redox Signal. 29(7), 653–666 (2018).Crossref, Medline, CAS, Google Scholar17. Duncan LF, Wang G, Ilyichova OV, Scanlon MJ, Heras B, Abbott BM. The fragment-based development of a benzofuran hit as a new class of Escherichia coli DsbA inhibitors. Molecules 24(20), 3756 (2019).Crossref, Google Scholar18. Aparna V, Dineshkumar K, Mohanalakshmi N, Velmurugan D, Hopper W. Identification of natural compound inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using in silico high-throughput virtual screening and in vitro validation. PLoS ONE 9(7), e101840 (2014).Crossref, Medline, Google ScholarFiguresReferencesRelatedDetailsCited ByAn elucidative study of the anti-biofilm effect of selenium nanoparticles (SeNPs) on selected biofilm producing pathogenic bacteria: A disintegrating effect of SeNPs on bacteriaProcess Biochemistry, Vol. 126Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy2 March 2023 | International Journal of Molecular Sciences, Vol. 24, No. 5How Does Time Affect the Antimicrobial Activity of Super-Oxidized Commercial Antiseptic Solutions? 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This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download

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