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Clinical use of an analysis of oxidative stress and IL-6 as the promoters of diabetic polyneuropathy

2020; Medical Association of Zenica-Doboj Canton; Volume: 18; Issue: 1 Linguagem: Inglês

10.17392/1279-21

1840-2445

E. Karahmet, Besim Prnjavorac, Tamer Bego, Adaleta Softić, Lejla Begić, Edin Begić, Esma Karahmet, Lejla Prnjavorac, Irfan Prnjavorac,

Diabetic Foot Ulcer Assessment and Management

<p><strong>Aim <br /></strong>To investigate interleukin 6 (IL-6) values depending on duration of diabetes mellitus (DM) and evaluate possible correlation<br />with diabetic polyneuropathy.<br /><strong>Methods</strong> <br />The research study included 90 patients with DM divided into three groups (30 patients each) according to the duration<br />of DM: group A – patients who had DM for less than 10 years, group B - duration of DM was 10 to 20 years, and group C - patients with DM over 20 years. Control group (K) included 30 healthy participants.<br /><strong>Results</strong> <br />IL-6 was significantly higher in the healthy control group, 180.318 pg/mL±94.18, than in group A, 47.23pg/ml±34.8, group B, 43.31pg/ml±33.17, and group C, 70.39 pg/ml±59.26 (p=0.0001). All groups had significantly different values of IL-6 between each other (p=0.0001). Level of IL-6 was in correlation with diabetic polyneuropathy in the group A (the youngest participants) (p=0.0001). In other groups there was no significant correlation between IL-6 and diabetic polyneuropathy.<br /><strong>Conclusion<br /></strong> The level of IL-6 was in correlation with neuropathy among younger patients. A higher level of IL-6 in the control group<br />than in diabetic groups is a sign of stronger inflammatory response among younger and healthy people than in patients with DM. </p>