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Oral contraceptive use and ovarian cancer risk for BRCA1/2 mutation carriers: an international cohort study

2021; Elsevier BV; Volume: 225; Issue: 1 Linguagem: Inglês

10.1016/j.ajog.2021.01.014

1097-6868

Lieske H. Schrijver, Antonis C Antoniou, Håkan Olsson, Thea M. Mooij, Marie-José Roos-Blom, Leyla Azarang, Julian Adlard, Munaza Ahmed, Daniel Barrowdale, Rosemarie Davidson, Alan Donaldson, Rosalind A. Eeles, D. Gareth Evans, Debra Frost, Alex Henderson, Louise Izatt, Kai-Ren Ong, Valérie Bonadona, Isabelle Coupier, Laurence Faivre, Jean‐Pierre Fricker, Paul Gesta, Klaartje van Engelen, Agnes Jager, Fred H. Menko, Marian J.E. Mourits, Christian F. Singer, Yen Y. Tan, Lenka Foretová, Marie Navrátilová, Rita K. Schmutzler, Carolina Ellberg, Anne–Marie Gerdes, Trinidad Caldés, Jacques Simard, Edith Oláh, Anna Jakubowska, Johanna Rantala, Ana Osório, John L. Hopper, Kelly‐Anne Phillips, Roger L. Milne, Mary Beth Terry, Catherine Noguès, Christoph Engel, Karin Kast, David E. Goldgar, Flora E. van Leeuwen, Douglas F. Easton, Nadine Andrieu, Matti A. Rookus, Catherine Noguès, Lilian Laborde, Pauline Pontois, Emanuelle Breysse, Margot Berline, Dominique Stoppa-Lyonnet, Marion Gauthier‐Villars, Bruno Buecher, Chrystelle Colas, Olivier Caron, Catherine Noguès, Emmanuelle Mouret‐Fourme, Claire Saule, Chrystelle Colas, Jean-Pierre Fricker, Christine Lasset, Valérie Bonadona, Sophie Dussard, Pascaline Berthet, Laurence Faivre, Elisabeth Luporsi, Véronique Mari, Laurence Gladieff, Paul Gesta, Stéphanie Chieze-Valéro, Jessica Moretta, Hagay Sobol, François Eisinger, Cornel Popovici, Michel Longy, Louise Grivelli, Chrystelle Colas, Florent Soubrier, Patrick Benusiglio, Isabelle Coupier, Pascal Pujol, Carole Corsini, Marie-Emmanuelle Morin-Meschin, Alain Lortholary, Claude Adenis, A. Maillez, Tan Dat Nguyen, Capucine Delnatte, Caroline Abadie, Julie Tinat, Isabelle Tennevet, Christine Maugard, Yves‐Jean Bignon, Mathilde Gay Bellile, Clotilde Penet, Hélène Dreyfus, Odile Cohen‐Haguenauer, Brigitte Gilbert, Laurence Venat-Bouvet, Dominique Leroux, Clémentine Legrand, Hélène Dreyfus, Hélène Zattara-Cannoni, Valérie Layet, Elodie Lacaze, Sandra Fert‐Ferrer, Odile Béra, Brigitte Gilbert-Dussardier, David Tougeron, Hakima Lallaoui, Julie Tinat, Matti A. Rookus, Frans B.L. Hogervorst, F.E. van Leeuwen, Muriel A. Adank, M.K. Schmidt, Denise J. Jenner, J.M. Collée, A.M.W. van den Ouweland, Maartje J. Hooning, Ingrid Boere, C.J. van Asperen, P. Devilee, Rob B. van der Luijt, T. C. T. E. F. van Cronenburg, M.R. Wevers, A.R. Mensenkamp, Margreet G.E.M. Ausems, Marco J. Koudijs, Irma van de Beek, Klaartje van Engelen, J.J.P. Gille, Encarna B. Gómez Garcia, Marinus J. Blok, Maaike de Boer, Lieke P.V. Berger, Annemarie H. van der Hout, Marian J.E. Mourits, Geertruida H. de Bock, Sabine Siesling, Janneke Verloop, Esther C. van den Broek,

Ovarian function and disorders

Ovarian cancer risk in BRCA1 and BRCA2 mutation carriers has been shown to decrease with longer duration of oral contraceptive use. Although the effects of using oral contraceptives in the general population are well established (approximately 50% risk reduction in ovarian cancer), the estimated risk reduction in mutation carriers is much less precise because of potential bias and small sample sizes. In addition, only a few studies on oral contraceptive use have examined the associations of duration of use, time since last use, starting age, and calendar year of start with risk of ovarian cancer.