Elastase and exacerbation of neutrophil innate immunity are involved in multi‐visceral manifestations of COVID‐19
2021; Wiley; Volume: 76; Issue: 6 Linguagem: Inglês
10.1111/all.14746
ISSN1398-9995
AutoresJean‐Louis Guéant, Rosa-Maria Guéant-Rodríguez, Julien Fromonot, Abderrahim Oussalah, Huguette Louis, Céline Chéry, Mickael Gette, Stanislas Gleye, Jonas Callet, Jérémie Raso, François Blanchecotte, Patrick Lacolley, Régis Guieu, Véronique Regnault,
Tópico(s)Neutrophil, Myeloperoxidase and Oxidative Mechanisms
ResumoMany arguments suggest that neutrophils could play a prominent role in COVID-19. However, the role of key components of neutrophil innate immunity in severe forms of COVID-19 has deserved insufficient attention. We aimed to evaluate the involvement of neutrophil elastase, histone-DNA, and DNases in systemic and multi-organ manifestations of COVID-19.
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