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Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients

2021; Oxford University Press; Volume: 3; Issue: 1 Linguagem: Inglês

10.1093/noajnl/vdab013

2632-2498

Elisa Izquierdo, Paula Proszek, Giulia Pericoli, Sara Temelso, Matthew Clarke, Diana Carvalho, Alan Mackay, Lynley V. Marshall, Fernando Carceller, Darren Hargrave, Birgitta Lannering, Zdeněk Pavelka, Simon Bailey, Natacha Entz‐Werlé, Jacques Grill, Gilles Vassal, Daniel Rodriguez Gutierrez, Paul S. Morgan, Tim Jaspan, Angela Mastronuzzi, Maria Vinci, Michael Hubank, Chris Jones,

Pancreatic and Hepatic Oncology Research

The use of liquid biopsy is of potential high importance for children with high grade (HGG) and diffuse midline gliomas (DMG), particularly where surgical procedures are limited, and invasive biopsy sampling not without risk. To date, however, the evidence that detection of cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) could provide useful information for these patients has been limited, or contradictory.