Artigo Acesso aberto Produção Nacional Revisado por pares

Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples

2021; Landes Bioscience; Volume: 13; Issue: 1 Linguagem: Inglês

10.1080/19490976.2021.1874740

ISSN

1949-0984

Autores

Lívia Bitencourt Pascoal, Patrícia Brito Rodrigues, Lívia Moreira Genaro, Arilson Bernardo dos Santos Pereira Gomes, Daniel A. Toledo-Teixeira, Pierina Lorencini Parise, Karina Bispo-dos-Santos, Camila L. Simeoni, Paula Veri Guimarães, Lucas I Buscaratti, João Gabriel de Angeli Elston, Henrique Marques‐Souza, Daniel Martins‐de‐Souza, Maria de Lourdes Setsuko Ayrizono, Lı́cio A. Velloso, José Luiz Proença-Módena, Pedro M. Moraes‐Vieira, Marcelo A. Mori, Alessandro Farias, Marco Aurélio Ramirez Vinolo, Raquel Franco Leal,

Tópico(s)

Long-Term Effects of COVID-19

Resumo

Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not change the entry or replication of SARS-CoV-2 in intestinal cells. These metabolites had no effect on intestinal cells' permeability and presented only minor effects on the production of anti-viral and inflammatory mediators. Together our findings indicate that the changes in microbiota composition of patients with COVID-19 and, particularly, of SCFAs do not interfere with the SARS-CoV-2 infection in the intestine.

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