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BIBTEX RIS

Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior

2021; Frontiers Media; Volume: 15; Linguagem: Inglês

10.3389/fnins.2021.631311

ISSN

1662-4548

Autores

Tadeu P. D. Oliveira, Bruno Daniel Correia Gonçalves, Bruna Silveira de Oliveira, Antônio Carlos Pinheiro de Oliveira, Helton José Reis, Cláudia N. Ferreira, Daniele C. Aguiar, Aline Silva de Miranda, Fabíola M. Ribeiro, Érica Leandro Marciano Vieira, András Palotás, Luciene Bruno Vieira,

Tópico(s)

Regulation of Appetite and Obesity

Resumo

Graphical Abstract Diet-induced obese (DIO) C57BL/6 mice were treated for 14 days with VU0409106, a negative allosteric modulator of mGluR5. Food intake, body weight, inflammatory/hormonal levels, and behavioral tests were performed. Our data suggest reduction of feeding, body weight, and adipose tissue inflammation in DIO mice after chronic treatment with VU0409106.

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