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BIBTEX RIS

SARS-CoV-2 Seroprevalence and Associated Factors in Manaus, Brazil: Baseline Results from the DETECTCoV-19 Cohort Study

2021; RELX Group (Netherlands); Linguagem: Inglês

10.2139/ssrn.3795816

ISSN

1556-5068

Autores

Pritesh Lalwani, Bárbara Batista Salgado, Ivanildo Vieira Pereira Filho, Danielle Severino Sena da Silva, Thiago Barros do Nascimento de Morais, Maele Ferreira Jordão, Aguyda Rayany Cavalcante Barbosa, Isabelle Bezerra Cordeiro, Júlio Nino de Souza Neto, Enedina Nogueira de Assunção, Rafaella Oliveira dos Santos, Nani Oliveira Carvalho, Wlademir Braga Salgado Sobrinho, Cristiano Fernandes da Costa, Pedro Elias de Souza, Bernardino Cláudio de Albuquerque, Christian A. Ganoza, Roger V. Araujo‐Castillo, Spartaco Astofi Filho, Jaila Dias Borges Lalwani, DETECTCoV- Study Team,

Tópico(s)

SARS-CoV-2 and COVID-19 Research

Resumo

Background: Manaus located in the Brazilian rainforest has twice experienced a health system collapse due to the SARS-CoV-2 pandemic. However, little is known about which groups among the general population have been more affected. Methods: A convenience sampling strategy via online advertising recruited 3046 adults. Sociodemographic characteristics, COVID-19-related symptoms, COVID-19 testing, self-medication and prescribed medications were recorded. Serum anti-SARS-CoV-2 nucleocapsid IgG antibodies were measured with an ELISA. Prevalence ratios (PR) were obtained using cluster-corrected and adjusted Poisson's regression models.Results: A crude positivity rate among asymptomatic and symptomatic individuals, was estimated at 29.10%, with a maximum seroprevalence of 41.53% corrected by test characteristics and an antibody decay rate of 27%. Regression models demonstrated a strong association towards marginalized low-income and vulnerable residents with limited health access. Presence of a COVID-19 case (PR 1.39, 1.24-1.57) or death (PR 2.14, 1.74-2.62) in a household increased greatly the risk of other household members acquiring infection. SARS-CoV-2 seroprevalence was higher among those who self-medicated to prevent infection (PR 1.36, 1.27-1.46). Conclusions: A disproportionate social and economic disparity was observed among the study participants. The syndemic nature of COVID-19 in the Amazon region needs differential policies and urgent solutions to control the ongoing pandemic.

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