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BIBTEX RIS

Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists

2021; Multidisciplinary Digital Publishing Institute; Volume: 28; Issue: 1 Linguagem: Inglês

10.3390/curroncol28010076

ISSN

1718-7729

Autores

Angel Ayumi Tome Uchiyama, Pedro Alexandre Ismael Amaral Silva, Moises S Martins Lopes, Cheng Tzu Yen, Eliza Dalsasso Ricardo, Taciana Sousa Mutão, Jefferson Rios Pimenta, Larissa M. Machado, Denis S Shimba, Renata D’Alpino Peixoto,

Tópico(s)

Cancer therapeutics and mechanisms

Resumo

Proton pump inhibitors (PPIs) are the most commonly used anti-acid drugs worldwide, including among cancer patients. However, drug-drug interactions between PPIs and other agents may lead to decreased drug absorption with possible reduced therapeutic benefit, or even increased toxicity. Unfortunately, only scarce data exist regarding the safety of concomitant PPI use with anti-cancer agents. We aim at reviewing current evidence on this possible interaction by dividing anti-cancer agents by class. Until further data is available, we encourage healthcare providers to limit unnecessary PPI overuse.

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